HER2: Reducing the Impact of Ovarian sTimulation – RIOT B

This study is an extension on the RIOT A study. 32 out of the planned 128 patients enrolled in the RIOT A study will have the study period expanded by a pre-study baseline examination and a post-study follow-up phase.

The key parameters measured is this study are various autocrine, paracrine and endocrine factors and there role in cyclic follicle recruitment, the interaction between ovarian stimulation and disruption of follicle recruitment induced by these hormonal factors and subsequently how suppression of supra-physiological estradiol with an aromatase inhibitor influences the endocrine environment.

Autocrine factors are chemical substances from endocrine cells, that bind to receptors on the same cell that produces them. Paracrine function is hormone function in which the effects of the hormone are restricted to the local environment. Endocrine function is defined as a physiological effect of a hormone in tissues in another part of the body.

This study is only performed at Herlev Hospital.

The findings from this study will improve our knowledge about how ovarian stimulation and follicle maturation and recruitment are controlled by changes in the hormonal milieu under normal and hyper-stimulation regimens. This understanding is key to our future optimisation and safety of IVF treatments.

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