LUND1: The association between fetal exposure to endocrine disrupters cerebral palsy

This study is performed at the Unit for Environmental Epidemiology at University of Lund.

Cerebral palsy (CP) is a term that includes a wide range of different motor impairments due to congenital malformation, injury based or other permanent function abnormality in the brain. The majority of all cerebral palsy occurs during fetal life, but can also occur during delivery. The aetiology of CP is unclear, but some risk factors have been identified. A strong association especially among boys between fetal exposure to fluorinated compounds and CP has been documented. These compounds are common in our everyday life, such as water repellents in clothing.

Since 1990 more 250 000 serum samples from pregnant women in Skåne have been collected in week 14 of pregnancy. From this register approximately 800 cases of diagnosed CP can be identified. 800 control cases of normal children will be obtained from the same register. Based on general health information from the Medical Birth Registry the link between maternal exposure to various hormone disrupting compounds and the occurrence of CP may be elucidated.

The size and quality of the data in this study gives a unique opportunity to increase the knowledge about the importance to reduce the general exposure to a fluorinated compounds in the overall environment, if the number of CP should be reduced in the future.

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