RH GR2: Semen quality: A marker of health
This study is performed at Rigshospitalet Department of Growth and Reproduction in collaboration with University of Lund.
Semen from healthy 18-20 years old men has since 1996 been collected by Rigshospitalet. More than 5.000 healthy men are included in this data base. Approximate 40 % of these men have in accordance with international criteria an impaired semen quality. 15 % will later need assistance to fertilize. It has been documented that an impaired semen quality is followed by a higher incidence of testicular cancer and cryptorchidism (lack of testicular descent to the scrotum). The mechanisms behind this connection is unknown, but exposure to hormonal disruptive compounds in early pregnancy, life style or genetic factors may contribute.
This project is a continuation of previous studies in healthy men. This project has the ambition to collect semen, evaluate life style factors and perform an extensive laboratory and physiological tests from 900 Danish and 900 Swedish men.
The hypothesis is that there may be a connection between some of these parameters and impaired semen quality. It will also be interesting to see if differences exist between Danish and Swedish men.
A new mass spectrophotometric analysis performed at University of Lund will try to identify proteomic biomarkers that can add information to the understanding of the pathogenesis of male infertility and associated disorders.