RH LRB1: The concentration of carbon fluoride and paracetamol in human embryos

This study is performed Laboratory of Reproductive Biology at Rigshospitalet in collaboration with Dept. Environmental Medicine at Lunds University.

Most pregnant women are concerned about exposure during pregnancy to various carbon flour rich toxins, smoking and frequently used medicines like paracetamol. The latter has been shown to have some effects on gonadal tissue early in pregnancy, effects that may lead to a reduced fertility later in life. Little is actually known about how much of these compounds that actually reaches the foetus, who is protected by the placenta barrier. It is still very uncertain how much of the chemicals and medicines that the mother is exposed to that pass this barrier and influence the growth and outcome of the child.

This study has a design that allows a simultaneous monitoring of maternal exposure and level of toxins in different embryo organs and tissue. Before a provoked abortion, the pregnant women fills out a questionnaire that addresses different aspects of life style and potential exposure. Blood samples from the mother is obtained and different organs and tissues are dissected from the removed embryo together with the placenta.

By measuring the concentrations of various compounds, toxins and medicines in the mother, the placenta and embryonic organs the transfer and accumulation of these can be documented.

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